Dynamic Process Control (MControl®) for Countercurrent Polish Processes (MCSGP)

The Contichrom® CUBE Combined and Contichrom HPLC systems use batch and continuous periodic countercurrent (PCC) processes for purification of target proteins, peptides, and small molecules. Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) is a unique PCC polishing process that provides superior yield and purity at high productivity. In order to keep the MCSGP process at an optimum, a process control algorithm, MControl®, is employed to offset any variation in conditions that could affect process performance. MControl® thus keeps the process at an optimum.